Our hundred and twenty, day old boiler chicks were randomly divided in to four groups viz. Group A (control), B (received aflatoxin @ 0.5 ppm and ochratoxin 0.5 ppm in diet), C (normal diet with probiotic, Sacchromyces boulardi @ 10 mg/ kg feed) and D (toxins as in group B with probiotic as in group C), containing 30 birds each, for a period of 6 weeks. Significant decrease in hemoglobin and PCV was observed in toxin fed birds along with serum proteins, albumin, globulin and A: G ratio when compared to the controls. Serum creatinine and SGPT levels were high in toxin fed birds. The genomic mean of antibody titers organist New Castle Disease were significantly low in toxin fed birds indicating immunosuppression. Sacchromycesboulardi appeared to act as probiotic and helped in combating the adverse effects of toxins, when compared with the hematobiochemical parameters.

Keyword: Aflatoxicocis; ochratoxicosis; broilers; probiotic (Sacchromyces Boulardi);